Dr. Lior Mayo

מנהלת הפקולטה למדעי החיים
Dr. Lior Mayo
Office: Britannia-Porter

Research Interests

Our lab strives to understand the mechanisms of chronic inflammation underlying neurologic diseases and translating these laboratory discoveries into new therapies. We take a transdisciplinary approach in this research endeavor combining immunologic, genomic, proteomic and metabolomic approaches to study brain inflammation.

 

We are particularly interested in:

  • Elucidating the immune function of the different glia, mainly astrocytes and NG2-Glia cells, in autoimmune and traumatic models of neurologic disorders.
  • Investigating the immunometabolic response in the Brain.
  • Studying the crosstalk between the innate and adaptive immune systems in the central nervous system.
  • Exploring the immunological aspects of the astrocyte–neuron relationship.
  • Developing novel strategies for manipulating glial activation and autoimmune responses.

 

Our research combines state of the art technologies such as genome-wide sequencing, genomic editing, molecular imaging, targeted and un-targeted mass-spectrometry and real-time metabolic analysis.

 

Recent publications

 

Ito Y, Ofengeim D, Najafov A, Das S,Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, Ouchida AT,Fan J, Pasparakis M, Kelliher MA, Ravits J & Yuan J. RIPK1 Mediates Axonal Degeneration by Promoting Inflammation and Necroptosis in ALS. Science. 2016 Aug 5;353(6299):603-8.

 

Mayo L, Pires Da Cunha A, Beynon V, Yang Z, Alvarez JI, Part A, Sobel RA, Kobzik L, Lassmann H, Quintana FJ, Weiner HL. IL-10 dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic CNS inflammation. Brain, 2016 Jul;139(7):1939-1957.

 

This work was highlighted by:

  • Zanvil SS and Winger RC K. Your nose knows how to target brain inflammation. Brain. 2016 Jul;139(7):1866-1869.

 

Rothhammer V, Mascanfroni DI, Bunse L, Takenaka M, Kenison J, Mayo L,  Chao C , Patel B, Yan R, Blain M, Alvarez JI, Kébir H, Anandasabapathy N,  Izquierdo G, Jung S, Obholzer N, Pochet N, Clish CB, Prinz M, Prat A, Antel J,  Quintana FJ. Modulation of astrocyte activity by type I interferon and dietary tryptophan limits inflammation in the central nervous system Nat Med. 2016 Jun;22(6):586-97

 

This work was highlighted by:

  • Marsland BJ. Regulating inflammation with microbial metabolites. Nat Med. 2016 Jun;22(6):581-3.

 

Mayo L, Trauger SA, Blain M, Nadeau M, Patel M, Alvarez JI, Mascanfroni ID, Yeste A, Kallas K, Bakshi R, Prat A, Antel JP, Weiner HL and Quintana FJ. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Nat. Med. 2014 Oct; 20(10):1147-56.

 

This work was highlighted by:

  •  Whalley K. Neurodegeneration: Active astrocytes drive inflammation. Nat Rev Neurosci. 2014 Oct; 15: 698 .
  • Rostami, A., & Ciric, B. Astrocyte-derived lactosylceramide implicated in multiple sclerosis. Nature Medicine, 2014 Oct; 20(10), 1092–1093.

 

Mascanfroni ID, Yeste A, Vieira SM, Burns EJ, Patel B, Sloma I, Wu Y, Mayo L,  Ben-Hamo R, Efroni S, Kuchroo VK, Robson SC, Quintana FJ. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat Immunol. 2013 Oct;14(10):1054-63.

 

Koeglsperger T, Li S, Brenneis C, Saulnier J, Mayo L, Carrier Y, Selkoe, Weiner HL. Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.  Glia. 2013 Jun;61(6):985-1002.

 

Mayo L, Quintana FJ, Weiner HL. The innate immune system in demyelinating disease. Immunol Rev. 2012 Jul;248(1):170-87.

 

Levy A, Blacher E, Vaknine H, Lund FE, Stein R, & Mayo L. CD38 deficiency in the tumor microenvironment attenuates glioma progression and modulates features of tumor-associated microglia/macrophages. Neuro Oncol. 2012 Aug;14(8):1037-49.

 

Mayo L, Levy A, Jacob-Hirsch J, Amariglio N, Rechavi G, Stein R. Bid regulates the immunological profile of murine microglia and macrophages. Glia. 2011 Mar;59(3):397-412.

 

Levy A, Bercovich-Kinori A, Alexandrovich AG, Tsenter J, Trembovler V, Lund FE, Shohami E, Stein R,   & Mayo L. CD38 facilitates recovery from traumatic brain injury. J Neurotrauma. 2009 Sep;26(9):1521-33.

 

Mayo L, Jacob-Hirsch J, Amariglio N, Rechavi G, Moutin MJ, Lund FE, & Stein R. Dual role of CD38 in microglial activation and activation-induced cell death. J Immunol. 2008 Jul 1;181(1):92-103.

 

Mayo L, & Stein R. Characterization of LPS and interferon-gamma triggered activation-induced cell death in N9 and primary microglial cells: induction of the mitochondrial gateway by nitric oxide. Cell Death Differ. 2007Jan;14(1):183-6.

 

Rothem L, Stark M, Kaufman Y, Mayo L, & Assaraf YG. Reduced folate carrier gene silencing in multiple antifolate-resistant tumor cell lines is due to a simultaneous loss of function of multiple transcription factors but not promoter methylation. J Biol Chem. 2004 Jan 2;279(1):374-84.

 

 

 

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